Research

Explore recent research on the natural ingredients used in Nic Nac nicotine lozenges and the harmful additives we deliberately avoid. Each ingredient is carefully chosen to provide a clean, guilt-free nicotine experience, and our commitment to transparency means you can trust that no artificial sweeteners, fillers, colors, or flavors are used.

It's important to note that neither Mick's Naturals nor Nic Nac has funded or influenced any of the research mentioned. We share these studies for educational purposes only and do not make any health claims based on their findings. Our mission is to offer a high-quality, natural nicotine alternative, and providing access to independent research aligns with our dedication to transparency and informed choice.

Beneficial effects of nicotine

Brain Pathway Links Nicotine and Weight Loss

Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity

The MIND Study: Memory Improvement through Nicotine Dosing

Nicotine Prevents Oxidative Stress-Induced Hippocampal Neuronal Injury Through α7-nAChR/Erk1/2 Signaling Pathway

Nicotine and inflammatory neurological disorders

Nicotine Increases Brain Functional Network Efficiency

Nicotine effects on default mode network during resting state

Anti-inflammatory effects of nicotine in obesity and ulcerative colitis

Transdermal nicotine attenuates depression symptoms in nonsmokers: a double-blind, placebo-controlled trial

Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects

Nicotine exposure alters in vivo human responses to endotoxin

Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study

Health benefits of xylitol

Xylitol acts as an anticancer monosaccharide to induce selective cancer death via regulation of the glutathione level

The effect of xylitol on dental caries and oral flora

Xylitol Affects the Intestinal Microbiota and Metabolism of Daidzein in Adult Male Mice

Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism

Xylitol’s Health Benefits beyond Dental Health: A Comprehensive Review

Nicotine-induced oxidative stress, testis injury, AChE inhibition and brain damage alleviated by Mentha spicata

Essential oils, their therapeutic properties, and implication in dentistry: A review

Is Sodium Carbonate in Snuff a Causative Factor for Oral Mucosal Lesions: A Cross-sectional Analysis

Artificial sweeteners and cancer risk: Results from the NutriNet-Santé population-based cohort study

Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays

Aspartame and cancer – new evidence for causation

The carcinogenic effects of aspartame: The urgent need for regulatory re-evaluation

First experimental demonstration of the multipotential carcinogenic effects of aspartame administered in the feed to Sprague-Dawley rats

Increasing brain tumor rates: is there a link to aspartame?